Mattapan, MA, United States
R&D Associate III-Process Development
GENERAL SUMMARY OF POSITION:
The Research Associate III is responsible to oversee upstream cell culture process development activities supporting development of media and feed supplements, optimization and scale-up of cell culture processes for the production of monoclonal antibodies and technical transfer to manufacturing. The Associate III will manage the preparation, formulation, and filteration cell culture basal media and reagents. Additionally, the Associate III will provide lab coverage during evenings, weekends, and holidays on a rotating basis, as required to support upstream development activities. The incumbent will perform established assays and contribute to the development of new assays.
Responsibilities MAJOR RESPONSIBILITIES:
Supervises cell culture maintenance in monolayer, shake flask, spinner flask and small-scale bench top bioreactor systems for the production of monoclonal antibodies.
Schedules experiments and maintains cell culture logs as required.
Performs analytical biochemistry and molecular biology assays as well as microscopy and other laboratory testing as required.
Keeps accurate records in notebooks, organize and report results.
Operates and maintains standard laboratory equipment and departmental specific equipment. Troubleshoots equipment within scope of experience.
Analyzes data in Excel and DOE software, and provides accurate, concise data summaries
Ensures timely and accurate documentation in accordance with cGMP and MassBiologics' SOPs. Contributes to the development of improved documentation processes.
Responsible to write protocols, project summaries and technical reports.
Prepares written and oral reports for presentation to the supervisor(s) and development group.
Maintains reagent and equipment inventories, orders supplies and cleans laboratory areas, hoods and common equipment.
Exercises technical discretion in the design, execution and interpretation of experiments that contribute to project strategies within defined parameters.
Trains junior personnel on techniques and equipment. May supervise lower level personnel.
Qualifications REQUIRED QUALIFICATIONS:
Requires a bachelor’s degree in Chemistry, Biochemistry, or related field with a minimum 5 years of relevant experience.
Hands on experience with antibody production in mammalian cell culture systems
Demonstrated ability to train and supervise others
Ability to follow instructions precisely, recognize deviations, and recommend corrective action within scope of training.
Possesses strong attention to detail, ability to maintain accurate records and excellent proofreading skills.
Ability to troubleshoot within scope of training.
Strong critical thinking, time management and organizational skills. Demonstrated ability to manage and prioritize multiple projects and consistently meet deadlines.
Excellent written and verbal communication skills. Ability to communicate effectively with others.
Ability to work effectively both independently and as a member of a team.
Computer literate and proficient in MS Word, Excel and other relevant electronic systems.
Occasionally projects require flexibility in work schedule to meet business needs.
Must be able to carry out the essential functions of this position,
ith reasonable accommodation if disabled
Reports to R&D Scientist II or designee
May supervise lower level personnel
ENVIRONMENTAL WORKING CONDITIONS:
Job may require working with hazardous and infectious materials. Employees will receive appropriate training and be required to adhere to UMBL policies and procedures.