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Scientist II/ Senior Scientist I Conjugation Chemist

Location
Worcester, MA, United States

Posted on
Nov 09,2019

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Education
Bachelor's Degree
Doctoral Degree
Master's Degree
Skills
Communication Skills
Protein Purification
Our Global Biologics Antibody Drug Conjugates (ADC) team located at the AbbVie Bioresearch Center in Worcester, MA is looking for a Conjugation Chemist to join their team! As a key member of the team, you will be responsible conduct pre-clinical research and development in the area of ADC!
Key Responsibilities:
Synthesis, purification and characterization of ADCs on mg to gram scale
Development and optimization of conjugation protocols utilizing novel chemistries and technologies
Demonstrating automated techniques for ADC synthesis and purification
Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie
Position will be hired based on level of experience.
Bachelors, Masters or Ph.D. in Organic Chemistry, Biochemistry, Chemical Biology or closely related field with typically 7-10+(BS), 5-8+(MS), 0+(Ph.D) years of experience; Industry experience preferred
Hands-on experience with generation and characterization of antibody drug conjugates; Preferably in the area of biotherapeutics
Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF)
Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography
Experience with GE AKTA FPLC and unicorn software preferred
This position requires an individual who is proactive, enthusiastic, hard-working, organized and able to work in a fast-paced team environment with proven problem solving skills
High-quality written and oral communication skills and the ability to excel in a collaborative environment are critical
Key Leadership Competencies:
Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
Learns fast, grasps the essence and can change course quickly where indicated
Raises the bar and is never satisfied with the status quo
Creates a learning environment, open to suggestions and experimentation for improvement
Embraces the ideas of others, nurtures innovation and manages innovation to reality

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