Job Details

Research Associate or Scientist in Organic Chemistry

Location
Santa Monica, CA, United States

Posted on
Feb 13,2020

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Position Summary General
We are seeking a highly motivated chemist with solid grounding in organic chemistry and an interest in medicinal chemistry. The successful candidate will join our Chemistry Group to work on projects in the pursuit of novel small molecules utilized in boron neutron capture therapy for curing diseases including cancer.
Organic Chemistry
The synthesis, scale up, and purification of common intermediates. Setting up reactions under standard and inert atmosphere (Schlenk Conditions).
Setting up reactions with varying temperatures from -76 °C to reflux.
Reactions techniques from mg to multi-gram scale.
Monitoring reactions as they run.
Purification: normal phase chromatography, reverse phase chromatography, extraction, crystallization, and trituration.
Identification and purity analysis of products via analytical techniques.
The syntheses of a new boron containing amino acid or peptides
Biochemistry
To assist in bio-conjugations, sample preparations and formulations.
Analytical Chemistry
To analyze samples with UPLC/MS, TLC, and NMR.
To assist with ICP-OES samples.
This role works in a collaborative environment with cell biology / antibody generation & pharmacology group.
Additionally for a Phd Candidite
An individual with a strong background in synthetic organic/medicinal chemistry. The successful candidate will be responsible for developing synthetic routes and chemical processes for small molecule prodrugs, and polymers for conjugation to biomolecules.
The tasks include Performing research in the laboratory as synthetic and medicinal chemist
Design and execute synthesis of organic molecules and biopolymers
Critically evaluate relevant scientific advances and integrate this knowledge into research programs
Instrumental in the intellectual property generation and patent filing
This role works in a collaborative environment with cell biology / antibody generation & pharmacology group
Experience in either polymer chemistry or boron chemistry is a plus
Responsibilities:
Work effectively with multidisciplinary team
Help maintain lab in a clean and orderly way
Articulate issues and options for resolution to upper management in a timely manner
Write reports on work and accomplishments
Present work at lab meetings
Present summary data to multi-disciplinary team
ADditional Responsibilities
PHD:
Lead molecules design and implementation and optimization using SAR and medicinal chemistry approaches
Optimize multiple parameters during lead generation effort based on strong knowledge of medicinal chemistry and understanding of key ADME, biochemical and pharmacological principles
Provide oversight for the transfer of chemical processes to third party CRO or CMO and develop novel and creative solutions to processing problems
Publish research in peer-reviewed journals
REQUIREMENTS:
BS or BA in Chemistry
Solid understanding of synthetic chemistry
Knowledge of purification and spectroscopic techniques utilized in the preparation and characterization of organic molecules
Strong track record of achievement in academic studies and in a laboratory environment
Meticulous note taking skills in the lab
Proficient in business and lab software
Logical thinker in methodology development and execution of multistep syntheses
Excellent written and oral communication skills; enthusiasm, integrity, self-motivation, and ability to interact within a multi-disciplinary team
Strong adherence to laboratory safety practices
REQUIREMENTS PHD:
Doctoral level degree in synthetic organic or medicinal chemistry.
Additional post-doctoral experience or Industrial experience in developing synthetic routes and chemical processes for active pharmaceutical ingredients is preferred
Highly proficient in advanced synthetic, purification and spectroscopic techniques utilized in the preparation and characterization of organic molecules
Inorganic boron chemistry experience, drug-linker experience for ADC/ liposome chemistry knowledge are a plus
Strong track record of achievement in synthesis of complex molecules with state of the art knowledge of modern synthetic methodologies and analytical and purification techniques
Expertise in methodology development and successfully completed multistep syntheses
Excellent written and oral communication skills; enthusiasm, integrity, self-motivation, and ability to interact within a multi-disciplinary team
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