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Senior Research Associate Biochemistry

Location
Cambridge, MA, United States

Posted on
Jul 12,2019

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Isolation and differentiation of primary antigen presenting cells from human PBMCs
Culturing and expansion of human T cells
Nucleic acid transfection and transduction of primary human cells and cell lines
Enzymatic labeling (e.g. biotinylation, fluorophore labeling) of proteins to generate reagents from downstream assays
Improvement of current processes and implementation for new technologies
Assist in laboratory operation duties for the group, such as inventory management and organization
Train members of the biochemistry team and other colleagues in the company as applicable
Track and compile methods and results in an electronic laboratory notebook
Regular presentation of results to wider research teams and other key stakeholders
Experience and Essential Skills MS in Immunology, Cell Biology, Biotechnology or similar field
At least 2 years post-educational laboratory experience
Strong skill set and hands-on experience in flow cytometry analysis of primary cells (8 colors or more), MHC tetramer experience is a plus
Primary immune cell isolation and culture, T cell cultures preferred
Exposure/training in protein expression and purification is desirable, but not required
Experience with immunological assays (e.g. ELIspot, ELISA)
Familiarity and hands-on experience with molecular cloning is highly preferred
Good understanding of structure-function relationship of proteins and knowledge of protein biochemistry would be beneficial
Demonstrated ability to analyze and communicate data to colleagues
Able to work both independently and on teams to deliver against timelines
Excellent attention to details, goal oriented, data driven and good organizational and communication skills (written and verbal), with a pro-active mentality
Strong inclination towards learning new techniques and developing new and strategic collaborations
Strong independent problem solving and troubleshooting skills, and ability to contribute constructively to scientific discussions
Resilience and adaptability to priority changes and work in the fast-paced biotech industry
Core Values At **MEMBERS ONLY**SIGN UP NOW***., our core values drive our actions ever day. Successful candidates will demonstrate and embody our company’s commitment to: Patients: Urgently develop life-changing medicines
People: Listen, Learn, Teach
Science: Creative, Rigorous, Uncompromising
Tenacity: Persevere, Build Neon to last
Pioneer: Leave the comfort zone, Create the future
Integrity: Do RIGHT
Equal Employment Opportunity **MEMBERS ONLY**SIGN UP NOW***. provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, **MEMBERS ONLY**SIGN UP NOW***. complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. Job Type: Full-time Experience: multicolor flow cytometry: 2 years (Required)
Education: Master's (Preferred)
Work Location: One location
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Senior Research Associate, Biochemistry
**MEMBERS ONLY**SIGN UP NOW***.
Cambridge, MA
17 hours ago
Full-time
Estimated: $70,000 - $97,000 a year
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Education
Master's Degree
Skills
Transfection
Biochemistry
Bioinformatics
Laboratory Experience
Troubleshooting
Company Summary
**MEMBERS ONLY**SIGN UP NOW***. is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. Neon utilizes its expertise in bioinformatics, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines. **MEMBERS ONLY**SIGN UP NOW***.’ lead program is NEO-PV-01, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute. NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb, in patients with measurable metastatic melanoma, non-small cell lung cancer and bladder cancer. Also in development are NEO-PTC-01, a bespoke autologous T cell therapy, and a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.
In addition, Neon has established strategic partnerships with CRISPR, Merck, and Apexigen, among others. By the end of 2018, it is anticipated there will be multiple clinical programs utilizing Neon’s platform.
**MEMBERS ONLY**SIGN UP NOW***. was incubated and launched by Third Rock Ventures, raised a $55M Series A in 2015, a $106M Series B in December 2017, and completed its IPO, raising $100M in the summer of 2018.
Position Summary
The successful candidate will serve a critical strategic role in ongoing technology development project that relate to detecting and characterizing antigen-specific T cells. In addition, the successful candidate will be expecting to serve as an intellectual leader / resource for other group members in the context of and functions as a conduit for fruitful collaborations across the company.
A successful candidate will embody and demonstrate commitment to Neon’s core values: Patients, People, Science, Tenacity, Pioneer, Integrity
Job Duties
Assessment of specificity and functionality of human T cells by multicolor flow cytometry
Analysis of multicolor flow cytometry data
Isolation and differentiation of primary antigen presenting cells from human PBMCs
Culturing and expansion of human T cells
Nucleic acid transfection and transduction of primary human cells and cell lines
Enzymatic labeling (e.g. biotinylation, fluorophore labeling) of proteins to generate reagents from downstream assays
Improvement of current processes and implementation for new technologies
Assist in laboratory operation duties for the group, such as inventory management and organization
Train members of the biochemistry team and other colleagues in the company as applicable
Track and compile methods and results in an electronic laboratory notebook
Regular presentation of results to wider research teams and other key stakeholders
Experience and Essential Skills
MS in Immunology, Cell Biology, Biotechnology or similar field
At least 2 years post-educational laboratory experience
Strong skill set and hands-on experience in flow cytometry analysis of primary cells (8 colors or more), MHC tetramer experience is a plus
Primary immune cell isolation and culture, T cell cultures preferred
Exposure/training in protein expression and purification is desirable, but not required
Experience with immunological assays (e.g. ELIspot, ELISA)
Familiarity and hands-on experience with molecular cloning is highly preferred
Good understanding of structure-function relationship of proteins and knowledge of protein biochemistry would be beneficial
Demonstrated ability to analyze and communicate data to colleagues
Able to work both independently and on teams to deliver against timelines
Excellent attention to details, goal oriented, data driven and good organizational and communication skills (written and verbal), with a pro-active mentality
Strong inclination towards learning new techniques and developing new and strategic collaborations
Strong independent problem solving and troubleshooting skills, and ability to contribute constructively to scientific discussions
Resilience and adaptability to priority changes and work in the fast-paced biotech industry
Core Values
At **MEMBERS ONLY**SIGN UP NOW***., our core values drive our actions ever day. Successful candidates will demonstrate and embody our company’s commitment to:
Patients: Urgently develop life-changing medicines
People: Listen, Learn, Teach
Science: Creative, Rigorous, Uncompromising
Tenacity: Persevere, Build Neon to last
Pioneer: Leave the comfort zone, Create the future
Integrity: Do RIGHT
Equal Employment Opportunity
**MEMBERS ONLY**SIGN UP NOW***. provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, **MEMBERS ONLY**SIGN UP NOW***. complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities.
Job Type: Full-time
Experience:
multicolor flow cytometry: 2 years (Required)
Education:
Master's (Preferred)
Work Location:
One location
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