Job added in hotlist
Applied job
Contract job
90-day-old-job
part-time-job
Recruiter job
Employer job
Expanded search
Apply online not available
View more jobs in La Jolla, CA
View more jobs in California

Job Details

Senior Research Associate / Scientist I Protein Chemistry

Company name
Synthorx, Inc.

Location
La Jolla, CA

Apply for this job






12 hit(s)  

Profile

Sr. Research Associate/ Scientist I, Protein Chemistry

The successful candidate will have a strong background in protein chemistry and bioconjugation.

Key Responsibilities:

Design, perform and optimize protein bioconjugation and related chemistries

Perform all steps of protein expression and purification, analytical and scale-up. Experience with

fermenters is a plus

Experimentally determine methods to optimize yields for expression, and potentially refolding of

proteins expressed in denatured form

Experience with production of peptides employing recombinant systems

Experience in peptide analysis, purification, and chemical modification

Develop standard operating procedures and document protocols

Maintain a high standard for quality control including up-to-date data records for all protein

deliveries, including basic understanding of mass spectrometry methods for QC

Troubleshoot challenging technical, experimental, and instrumental issues

Consummate ability to work in a highly collaborative, fast-paced, cross-functional environment,

with strong oral and written communication skills

Required:

Masters or Ph.D. in chemistry, biochemistry, biophysics, or related field, and 5 years of handson experience with recombinant protein production, protein/peptide chemistry and bioconjugation

Experience using E. coli for protein expression. Scale-up preparation employing fermentation

instrumentation and protocols is a plus

Experience developing methods and optimizing workflows for protein purification, including

refolding steps

Chromatography by affinity, IEX, and SEC. HPLC peptide analysis and purification is a plus

Experience in protein characterization (SDS PAGE, Western Blotting, quantification).

Understanding of MS methods for QC

Technical proficiency with standard molecular biology methods

Regular activities require ability to communicate effectively and rapidly reprioritize to match

dynamic and demanding timelines

Additional preferred skills:

Strong understanding of cancer and/or immuno-biology

Experience with mammalian cell culture systems and cell-based assay development and

application.

Biochemical assay/screen development

Peptide chemistry applied to SAR for therapeutic peptides or biologic drugs

Applicant Documents:

Curriculum Vitae

Job Type

Permanent

Job Reference

194645af305049e

Job ID

19457302

Enter your details to join Resume-Library and apply for this role

Email

First Name

Last Name

This email already exists

Enter your password to login and apply

Forgotten your password?

Apply Now

Company info

Synthorx, Inc.

Company Profile

Similar Jobs:
Manufacturing Systems Engineer
location Irwindale, CA
10711BR Auto req ID: Posting Title: Country:Job Description:Works with the assigned plant functional departments to ensure that systems are being fully utilized and add value to the department and the teamsIs the single poi...
Save Johnson & Johnson’s Cardiovascular & Specialty Solutions (CSS) Group within Medical Devices is recruiting for a Director of Quality and Compliance for Mentor Worldwide located in Irvine, CA or Irving, TX. The CSS Group serves...
Analyst, Claims - Pet
location Brea, CA
#veteran #nationwide #diversity ADDITIONAL INFORMATION - PLEASE READ CAREFULLY The information between the asterisks contains specific information about this position while the information after the asterisks contains general info...
I was facing the seven-year itch at my previous workplace. Thanks to EmploymentCrossing, I'm committed to a fantastic sales job in downtown Manhattan.
Joseph L - New York, NY
  • All we do is research jobs.
  • Our team of researchers, programmers, and analysts find you jobs from over 1,000 career pages and other sources
  • Our members get more interviews and jobs than people who use "public job boards"
Shoot for the moon. Even if you miss it, you will land among the stars.
ChemistryCrossing - #1 Job Aggregation and Private Job-Opening Research Service — The Most Quality Jobs Anywhere
ChemistryCrossing is the first job consolidation service in the employment industry to seek to include every job that exists in the world.
Copyright © 2018 ChemistryCrossing - All rights reserved. 169