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Job Details

Senior Research Associate / Scientist I Protein Chemistry

Company name
Synthorx, Inc.

La Jolla, CA

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Sr. Research Associate/ Scientist I, Protein Chemistry

The successful candidate will have a strong background in protein chemistry and bioconjugation.

Key Responsibilities:

Design, perform and optimize protein bioconjugation and related chemistries

Perform all steps of protein expression and purification, analytical and scale-up. Experience with

fermenters is a plus

Experimentally determine methods to optimize yields for expression, and potentially refolding of

proteins expressed in denatured form

Experience with production of peptides employing recombinant systems

Experience in peptide analysis, purification, and chemical modification

Develop standard operating procedures and document protocols

Maintain a high standard for quality control including up-to-date data records for all protein

deliveries, including basic understanding of mass spectrometry methods for QC

Troubleshoot challenging technical, experimental, and instrumental issues

Consummate ability to work in a highly collaborative, fast-paced, cross-functional environment,

with strong oral and written communication skills


Masters or Ph.D. in chemistry, biochemistry, biophysics, or related field, and 5 years of handson experience with recombinant protein production, protein/peptide chemistry and bioconjugation

Experience using E. coli for protein expression. Scale-up preparation employing fermentation

instrumentation and protocols is a plus

Experience developing methods and optimizing workflows for protein purification, including

refolding steps

Chromatography by affinity, IEX, and SEC. HPLC peptide analysis and purification is a plus

Experience in protein characterization (SDS PAGE, Western Blotting, quantification).

Understanding of MS methods for QC

Technical proficiency with standard molecular biology methods

Regular activities require ability to communicate effectively and rapidly reprioritize to match

dynamic and demanding timelines

Additional preferred skills:

Strong understanding of cancer and/or immuno-biology

Experience with mammalian cell culture systems and cell-based assay development and


Biochemical assay/screen development

Peptide chemistry applied to SAR for therapeutic peptides or biologic drugs

Applicant Documents:

Curriculum Vitae

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Company info

Synthorx, Inc.

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