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Job Details

Sr Scientist - Process Development Sequencing

Company name
F. Hoffmann-La Roche Ltd

Location
Santa Clara, CA

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'Sr Scientist - Process Development, Sequencing','3600323319','!*!Roche Sequencing Solutions is a fast moving, highly technical team of people with the ambitious goal of disrupting Next Generation DNA Sequencing. Our technology fuses active biological and solid state elements to bring single molecule based sequence detection to scale. Developing this unique platform requires expertise across a range of fields: Software Engineering, Data Science, Information Theory, Biophysics, Biology, Chemistry, Protein Engineering, Digital and Analog Circuit Design, and Electrochemistry, just to name a few.We are looking for a highly motivated, passionate and team-oriented individual who has demonstrated abilities in developing robust analytical methods for the characterization of reagents and enzymes. As part of our bioproduction team, you will develop analytical methods correlated to system performance, in-coming QC for the raw materials, and in-process QC of manufactured proteins and reagents. In addition to developing these methods, you will work with the group to purify proteins and produce sequencing reagents. Experience in protein purification, characterization of DNA polymerase and/or membrane proteins, generation and qualification or reagents is highly desired.Responsibilities Include:Formulation and stability of enzymes and protein conjugatesCharacterizing polymerases and membrane proteins, including analytical HPLC, DLS, DSF and other biochemical and biophysical methodsReagent production, characterization and tracking QC resultsExpression of DNA polymerases and other membrane proteins in E. Coli and their purification using AKTA FPLC systemDocumenting and writing up production protocols and batch records ','You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. ','Where a job title is not considered the final definition of who you are, but the starting point.','!*!Ph.D. in biochemistry, chemistry, molecular biology or related discipline or M.S./B.S with equivalent industrial experienceStrong familiarity with chromatography methods such as AEX, CEX, SEC and affinity using AKTA and analytical HPLC instruments such as Infinite 1260, etc. is a requirement Previous experience with developing and executing DNA polymerase assays, DNA-protein interaction assay is desirable Demonstrated experience with protein conjugation techniques, protein-protein attachment, and fluorescent labelingPrevious exposure to protein structural and functional analysis and characterization techniques such as DLS, DSF, fluorescent spectroscopy, CD, ELISA, MS, etc. is a plusDemonstrated meticulous documentation capabilitiesDemonstrated strong analytical skills with methodical approaches to trouble-shootingExperience in writing and following Work Instructions, Batch Records and Standard Operating Procedures is a plusDemonstrated critical thinking and meticulous attention to detailStrong oral and written communication skills is a mustMust be able to lift 25 lbs','The next step is yours. To apply today, click on the Apply now button.','At Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.','At Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.','','','Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, ','age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.','','','','','','','Chemistry','US-USCA-Santa Clara','','Full-time','Regular Employee','Individual Contributor','Diagnostics','Diagnostics','Sr Scientist - Process Development, Sequencing

Company info

F. Hoffmann-La Roche Ltd
Website : http://www.roche-diagnostics.co.in/Pages/default.aspx

Company Profile
The founding year – first successes F. Hoffmann-La Roche & Co. was founded at a time when industrial revolution was changing the face of Europe. On October 1, 1896, at the age of 28, Fritz Hoffmann-La Roche launched his company as the successor company to Hoffmann, Traub & Co in Basel, Switzerland. He was among the first to recognise that the industrial manufacture of medicines would be a major advance in the fight against disease. Since then, Roche has grown into one of the world's leading healthcare companies. First products Pharmacist Carl Schaerges, the first head of research, together with chemist Emil C. Barell demonstrate the presence of iodine in thyroid extracts. This results in Roche’s first patent and scientific publications. The launch of Aiodin marks the earliest in a series of thyroid preparations by Roche.

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