Takeda Pharmaceutical Company Limited.
Boston, MA, United States
Sciences, Scientist, Chemistry, Engineering, Pharmaceutical
Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda.Â Join us as a Scientist, Cell Product Clinical Translation in our Cambridge office.
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Scientist working on the Cell Product Clinical Translation team, you will be empowered to provide scientific expertise and work with stakeholders across multiple functions at Takeda, and a typical day will include:Â
The Cell Product Clinical Translation team is uniquely positioned to link CMC and clinical CART biomarkers to investigate correlatives associated with cell product efficacy and safety in oncology indications. This positionâ€™s primary role is to provide scientific expertise and project leadership in integrating cross-functional biomarker data from multiple platforms and line functions to investigate safety, efficacy and mechanisms of resistance and relapse in cell therapies. In this unique role you will be at the scientific forefront of cell therapies striving towards improving outcomes for patients with B cell malignancies and solid tumors through in-depth product characterization and establishing biomarker strategies.
Investigates mode of action (MoA), critical quality attributes (CQA) and mechanisms of resistance and relapse in cell therapies through collaboration and integration of biomarker data from process development, manufacturing (CMC), product characterization, animal models, tumor microenvironment, clinical biomarkers, pharmacology, safety and efficacy.
Represents functional area on GCT project teams by communicating activities from designated functional area to project team
Prepares study protocols, reports, technology transfer documentation, and regulatory documents for clinical trials.Â
Understands project timelines and deliverables and plans/coordinates project work accordingly with departmental, functional and external stakeholders
Reviews, interprets and communicates data cross-functionally within CMC and/or project teams.
Supports local and global initiatives which may include leading initiatives or work streams
EDUCATION, EXPERIENCE, BEHAVIOURAL COMPETENCIES AND SKILLS:
Education and Experience:
Bachelors degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science and 8 years relevant industry experience
Masters degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; 6 years relevant industry experience
PhD in chemistry, biology, pharmacy, chemical or biomedical engineering or related pharmaceutical science; 0 years relevant industry experience
Experience in CART, immunology, immune-oncology, vaccines or virology with strong understanding of solid tumor or B cell malignancies
In-depth knowledge of various mechanisms of therapeutic response and resistance mechanisms utilizing in vitro, in vivo or ex vivo patient-derived models
Understanding of current therapeutic and combination therapy landscape, including immune-checkpoint blockade, in cancer immunotherapy
Experience with immune-phenotyping by FACS (flow cytometry), primary cell culture, immunofluorescence, ELISA, and PCR
A track record of independent critical thinking and scientific achievement demonstrated by national presentations and publications
Prior experience with translational aspects of IND, NDA or BLA desirable
Knowledge and Skills:
Analytical and Problem Solving Skills - Able to troubleshoot critical issues or problems using appropriate information and, determine causes and possible solutions
Teamwork -- Ability to work well on global cross-functional teams.
Communication Skills -Able to expresses oneâ€™s self clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjusts communication style as appropriate for the audience; timely and effectively communicates withÂ senior management; technical writing skills to support authorship and approval of internal technical documents
Organization â€“ Exercises good time management and prioritization skills to balance multiple project and departmental objectives
Technical - Subject matter expertise in a specific scientific area or areas. Demonstrated ability to successfully contribute across multiple scientific endeavors
Knowledge Sharing - Ability to capture knowledge within the organization; improves solutions, processes, and deliverables through use of information; improves information capital by contributing experience, theories, deliverables, and models for others to use
Resource Management -Project management skills; ability to manage oneâ€™s time within individual, departmental, and corporate goals and timelines; management of internal external resources (vendors)
External Involvement â€“ Demonstrated involvement in professional community evidenced by presentation of scientific posters or lectures at professional conferences or events. Interacts with external vendors for projects
Leadership Skills â€“ Develops and uses knowledge and interpersonal skills to appropriately influence and guide others towards the accomplishment of department/function goals and objectives.
May require approximately 10% travel
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Learn more at takedajobs.com
No Phone Calls or Recruiters Please.
Takeda Pharmaceutical Company Limited.
Website : https://www.takeda.com
As a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Takeda Pharmaceuticals U.S.A., Inc. (TPUSA) is among the top 15 pharmaceutical companies in the United States. TPUSA was founded in 1998 to accelerate Takeda's global expansion into the U.S. market. Takeda's U.S. clinical development activities are conducted via Takeda Development Center Americas, Inc., which has a robust pipeline of compounds in multiple therapeutic areas including metabolic and cardiovascular diseases, central nervous system, respiratory and immunology, oncology and general medicine. Striving toward better health is at the center of everything we do. Takeda is enjoying tremendous growth as an emerging global leader in the pharmaceutical industry, but remains ever mindful of our commitment to serve people worldwide by striving toward better health through leading innovation in medicine.The spirit of our commitment extends to our employees, partners and the larger community.